Long-term results of forward intensity-modulated radiation therapy for patients with early-stage breast cancer
Identifieur interne : 003493 ( Main/Exploration ); précédent : 003492; suivant : 003494Long-term results of forward intensity-modulated radiation therapy for patients with early-stage breast cancer
Auteurs : Boram Ha [Corée du Sud] ; Hyun Suk Suh [Corée du Sud] ; Jihae Lee [Corée du Sud] ; Kyung-Ja Lee [Corée du Sud] ; Rena Lee [Corée du Sud] ; Byung In Moon [Corée du Sud]Source :
- Radiation Oncology Journal [ 2234-1900 ] ; 2013.
Abstract
To observe long-term clinical outcomes for patients with early-stage breast cancer treated with forward intensity-modulated radiation therapy (IMRT), including local control and clinical toxicities.
We retrospectively analyzed a total of 214 patients with stage I-II breast cancer who were treated with breast conserving surgery followed by adjuvant breast radiation therapy between 2001 and 2008. All patients were treated using forward IMRT. The whole breast was irradiated to a dose of 50 to 50.4 Gy followed by an 8 to 12 Gy electron boost to the surgical bed.
The median age was 46 years (range, 21 to 82 years) and the medial follow-up time was 7.3 years (range, 2.4 to 11.7 years). Stage T1 was 139 (65%) and T2 was 75 (35%), respectively. Ipsilateral breast recurrence was observed in 3 patients. The 5- and 10-year local control rates were 99.1% and 97.8%, respectively. The cosmetic outcome was evaluated according to the Harvard scale and 89.4% of patients were scored as excellent or good.
The whole breast radiation therapy as an adjuvant treatment using a forward IMRT technique showed excellent long-term local control as well as favorable outcomes of toxicity and cosmesis.
Url:
DOI: 10.3857/roj.2013.31.4.191
PubMed: 24501706
PubMed Central: 3912232
Affiliations:
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type="main">Long-term results of forward intensity-modulated radiation therapy for patients with early-stage breast cancer</title><author><name sortKey="Ha, Boram" sort="Ha, Boram" uniqKey="Ha B" first="Boram" last="Ha">Boram Ha</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Suh, Hyun Suk" sort="Suh, Hyun Suk" uniqKey="Suh H" first="Hyun Suk" last="Suh">Hyun Suk Suh</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Jihae" sort="Lee, Jihae" uniqKey="Lee J" first="Jihae" last="Lee">Jihae Lee</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Kyung Ja" sort="Lee, Kyung Ja" uniqKey="Lee K" first="Kyung-Ja" 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type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Moon, Byung In" sort="Moon, Byung In" uniqKey="Moon B" first="Byung In" last="Moon">Byung In Moon</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of General Surgery, Ewha Womans University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of General Surgery, Ewha Womans University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Radiation Oncology Journal</title><idno type="ISSN">2234-1900</idno><idno type="eISSN">2234-3164</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To observe long-term clinical outcomes for patients with early-stage breast cancer treated with forward intensity-modulated radiation therapy (IMRT), including local control and clinical toxicities.</p></sec><sec><title>Materials and Methods</title><p>We retrospectively analyzed a total of 214 patients with stage I-II breast cancer who were treated with breast conserving surgery followed by adjuvant breast radiation therapy between 2001 and 2008. All patients were treated using forward IMRT. The whole breast was irradiated to a dose of 50 to 50.4 Gy followed by an 8 to 12 Gy electron boost to the surgical bed.</p></sec><sec><title>Results</title><p>The median age was 46 years (range, 21 to 82 years) and the medial follow-up time was 7.3 years (range, 2.4 to 11.7 years). Stage T1 was 139 (65%) and T2 was 75 (35%), respectively. Ipsilateral breast recurrence was observed in 3 patients. The 5- and 10-year local control rates were 99.1% and 97.8%, respectively. The cosmetic outcome was evaluated according to the Harvard scale and 89.4% of patients were scored as excellent or good.</p></sec><sec><title>Conclusion</title><p>The whole breast radiation therapy as an adjuvant treatment using a forward IMRT technique showed excellent long-term local control as well as favorable outcomes of toxicity and cosmesis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jung, Kw" uniqKey="Jung K">KW Jung</name></author><author><name sortKey="Park, S" uniqKey="Park S">S Park</name></author><author><name sortKey="Won, Yj" uniqKey="Won Y">YJ Won</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name sortKey="Collins, R" uniqKey="Collins R">R Collins</name></author><author><name sortKey="Darby, S" uniqKey="Darby S">S Darby</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frazier, Rc" uniqKey="Frazier R">RC Frazier</name></author><author><name sortKey="Vicini, Fa" uniqKey="Vicini F">FA Vicini</name></author><author><name sortKey="Sharpe, Mb" uniqKey="Sharpe M">MB Sharpe</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Ha, Boram" sort="Ha, Boram" uniqKey="Ha B" first="Boram" last="Ha">Boram Ha</name></region><name sortKey="Lee, Jihae" sort="Lee, Jihae" uniqKey="Lee J" first="Jihae" last="Lee">Jihae Lee</name><name sortKey="Lee, Kyung Ja" sort="Lee, Kyung Ja" uniqKey="Lee K" first="Kyung-Ja" last="Lee">Kyung-Ja Lee</name><name sortKey="Lee, Rena" sort="Lee, Rena" uniqKey="Lee R" first="Rena" last="Lee">Rena Lee</name><name sortKey="Moon, Byung In" sort="Moon, Byung In" uniqKey="Moon B" first="Byung In" last="Moon">Byung In Moon</name><name sortKey="Suh, Hyun Suk" sort="Suh, Hyun Suk" uniqKey="Suh H" first="Hyun Suk" last="Suh">Hyun Suk Suh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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